Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future

Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future

Blog Article

Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for liftmaster csl24ul gate control diabetic complications, introducing a turning point in this field of research.For the first time, reactive oxygen species (ROS) were identified as the causal link between hyperglycemia and four seemingly independent pathways that are involved in the pathogenesis of diabetes-associated vascular disease.Before and after this milestone in diabetes research, hundreds of articles describe a role for ROS, but the failure of clinical trials to demonstrate antioxidant benefits and some recent experimental studies showing that ROS are dispensable for the pathogenesis of diabetic complications call for time to reflect.This twenty-year journey focuses on the most relevant literature regarding the main sources of ROS generation in diabetes and their role in the pathogenesis of cell dysfunction and diabetic complications.

To identify future research directions, this review discusses the evidence in favor and against oxidative stress as an initial event in the cellular biochemical abnormalities induced by hyperglycemia.It also explores possible alternative mechanisms, including carbonyl stress and the Warburg effect, linking glucose and lipid excess, mitochondrial dysfunction, and the activation of alternative pathways of glucose citroen c4 grand picasso boot liner metabolism leading to vascular cell injury and inflammation.